Robert Rosen wrote extensively about many scientific subjects, with a research stream that always circled back to the essential question of 'What is life?' Below you can access most of his published work, as well as some unpublished notes, including the primary ideas that led to the development of Life Itself I: Epistemology, and its intended sequel, Life Itself II: Ontology.
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On control and optimal control in biodynamic systems

In control systems with fewer independent controls than degrees of freedom, the resulting constraints have significant implications for biological adaptation, aging, polypeptide structure, and the optimality of biodynamic systems

Topics:

Control
Dynamical Systems
Senescence
Protein Folding
Dated
Article
1980

On explaining creativity

This paper critiques the limitations of current causal paradigms in understanding creativity and innovation, linking them to the broader concept of emergence while arguing that biological evolution and human creativity have distinct causal structures

Topics:

Creativity
Causality
Evolution
Final Cause
Morphogenesis
Dated
Commentary
1988

On interactions between dynamical systems

This paper presents a method to infer the dynamics and interaction of an unknown system T with a known system S, contributing to the theory of measurement and its applications in biological contexts

Topics:

Dynamical Systems
Measurement
Interaction
Realization
Dated
Article
1975

On models and modeling

Biological modeling should acknowledge the constraints of simulation and reductionism

Topics:

Modelling
Simulation
Reductionism
Dated
Article
1993

On non-quantum quantization

The limitations of quantum theory, rooted in Hamilton's Principle, highlight its inadequacy in addressing the nonlinear complexities of self-organization in biological systems

Topics:

Quantum
Dynamical Systems
Constraints
Organization
Dated
Commentary
1983
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