Robert Rosen wrote extensively about many scientific subjects, with a research stream that always circled back to the essential question of 'What is life?' Below you can access most of his published work, as well as some unpublished notes, including the primary ideas that led to the development of Life Itself I: Epistemology, and its intended sequel, Life Itself II: Ontology.
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Structural stability, alternate descriptions and information

This article explores how distinct descriptions of complex biological systems relate to each other, particularly focusing on when they convey equivalent information and the implications of these relationships for understanding system stability and bifurcation points

Topics:

Complexity
Information
Topology
Dated
Article
1976

Subunit and subassembly processes

This note evaluates optimal subassembly procedures to maximize error-free final structures while minimizing subassembly stages, building on Crane's 1950 insights

Topics:

Assembly
Error
Biological Systems
Dated
Article
1970

System closure and dynamical degeneracy

Contemporary physics reveals that the mathematical descriptions of material systems are often nongeneric and degenerate, particularly in classical thermodynamics, leading to significant implications for understanding closed versus open systems, irreversible processes, and the relationship between disorder and system closure

Topics:

Thermodynamics
Reductionism
Generic
Open Systems
Dated
Article
1988

The DNA-protein coding problem

The study presents an algebraic framework for the DNA-protein coding problem, revealing the existence of infinitely many abstract codes and introducing ergodicity to derive a potential natural code while questioning the possibility of multiple codes in nature

Topics:

Ergodicity
DNA
Proteins
Dated
Article
1959

The derivation of D'Arcy Thompson's theory of transformations from the theory of optimal design

Cohn's theory of Optimal Forms can be viewed as a comparative theory that leads to D'Arcy Thompson's transformation theory, with implications for comparative morphology and suggestions for further development

Topics:

Optimality
Form
D'Arcy Thompson
Morphology
Dated
Article
1962
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