Robert Rosen wrote extensively about many scientific subjects, with a research stream that always circled back to the essential question of 'What is life?' Below you can access most of his published work, as well as some unpublished notes, including the primary ideas that led to the development of Life Itself I: Epistemology, and its intended sequel, Life Itself II: Ontology.
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Role of similarity principles in data extrapolation

An exploration of the challenges and limitations of extrapolating data from specific systems to broader physiological contexts, emphasizing the need for a deeper understanding of similarity and modeling in scientific research

Topics:

Similarity
Modelling
Scaling
Genotype
Phenotype
Dated
Commentary
1983

Second W Ross Ashby memorial lecture 1984 the physics of complexity

Rosen's reflections on his brief but impactful interactions with W. Ross Ashby, expressing honor in presenting the Ashby Memorial Lecture while critically reviewing Ashby's influential ideas on the brain, biology, and complexity

Topics:

Complexity
Reductionism
Causality
Determinism
Dated
Lecture
1984

Self-reproducing automaton

Clarification on some fundamental misunderstandings on von Neumman's 1959 paper on self-reproduction, emphasizing the lack of a rigorous definition for the term and the resulting confusion in its varied interpretations

Topics:

Automata
Reproduction
von Neumann
Dated
Commentary
1962

Self-sorting of isotropic cells

The study explores Steinberg's hypothesis on cell self-sorting, suggesting that motility and differential adhesion can lead to stable configurations with minimal surface free energy, but computer simulations reveal that achieving maximum energy configurations may require specific, yet undetermined, rules of cell motility

Topics:

Cells
Morphogenesis
Cell Sorting
Motility
Adhesion
Dated
Article
1970

Similarity and dissimilarity- A partial overview

The concept of similarity and dissimilarity is fundamental in science and mathematics, influencing our understanding of physical reality, as illustrated through examples from biology and technology

Topics:

Similarity
Scaling
Bifurcation
Self-Organization
Dated
Article
1988
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