Robert Rosen wrote extensively about many scientific subjects, with a research stream that always circled back to the essential question of 'What is life?' Below you can access most of his published work, as well as some unpublished notes, including the primary ideas that led to the development of Life Itself I: Epistemology, and its intended sequel, Life Itself II: Ontology.
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On the dynamical realization of automata

The concept of dynamical realizability is introduced for mappings between sets, demonstrating that finite automaton next-state maps are dynamically realizable and highlighting the complementary relationship between dynamical and automata-theoretic descriptions

Topics:

Realization
Automata
Dynamical Systems
Dated
Article
1975

On the limitations of scientific knowledge

Rosen challenges the notion that the question "What is Life?" is unscientific, arguing instead that it is central to science and solvable, despite the limitations of methods that rely on artificially simplified models of reality

Topics:

Objectivity
Complexity
Computation
Dated
Chapter
1996

On the relation between structural and functional descriptions of biological systems

The paper examines various system description frameworks used to address fundamental biological problems, highlighting their scope, limitations, and interrelationships

Topics:

Structure
Function
Biological Systems
Dated
Article
1972

On the reversibility of environmentally induced alterations in abstract biological systems

The study investigates the reversibility of environmentally induced structural changes in (M,R)-systems with metabolic and genetic components, providing conditions for the metabolic component while noting complexities for the genetic component

Topics:

(M,R)-Systems
Genetics
Metabolism
Dated
Article
1963

On the role of chemical systems in the microphysical aspects of primary genetic mechanisms

The text contrasts two views of genetic processes‚ one as a communication-theoretic model with real information transfer and the other as a template scheme lacking true genetic information‚ while exploring their implications through microphysical principles and suggesting that templates are unlikely to play a primary role in genetics

Topics:

Information
Genetics
DNA
Communication
Dated
Article
1961
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