Robert Rosen wrote extensively about many scientific subjects, with a research stream that always circled back to the essential question of 'What is life?' Below you can access most of his published work, as well as some unpublished notes, including the primary ideas that led to the development of Life Itself I: Epistemology, and its intended sequel, Life Itself II: Ontology.
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Some comments on re-establishability

This note presents a new graph-theoretic proof of the existence of a non-reestablishable component in (M,R)-systems and explores the relationship between re-establishability and time-lag structure in them

Topics:

(M,R)-Systems
Re-Establishability
Time
Dated
Article
1965

Some comments on systems and system theory

The concept of "systemhood" is proposed as a distinct aspect of entities, separate from their inherent "thinghood," drawing parallels to the mathematical abstraction of sets from specific aggregates

Topics:

Systems Theory
Set Theory
Numbers
Reductionism
Dated
Article
1986

Some comments on the concepts of regulation and positional information in morphogenesis

This article redefines Wolpert's metaphorical concepts of 'positional information' and 'regulation' in morphogenesis within a broader dynamical framework, emphasizing their stability properties in various dynamical systems

Topics:

Information
Dynamical Systems
Morphogenesis
Dated
Article
1971

Some comments on the physico-chemical description of biological activity

Contemporary biology's reliance on analytical physico-chemical techniques overlooks important system-theoretic questions, suggesting a need for a broader approach in relational biology to fully understand diverse biological systems

Topics:

Relational Biology
Fractionation
Emergence
Subsystems
Dated
Article
1968

Some further comments on the DNA-protein coding problem

The concept of quasi-ergodicity in free monoids is introduced and analyzed, revealing similarities to previous findings and establishing conditions that limit the diversity of DNA-protein codes in nature

Topics:

Ergodicity
DNA
Proteins
Dated
Article
1959
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