Robert Rosen wrote extensively about many scientific subjects, with a research stream that always circled back to the essential question of 'What is life?' Below you can access most of his published work, as well as some unpublished notes, including the primary ideas that led to the development of Life Itself I: Epistemology, and its intended sequel, Life Itself II: Ontology.
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Optimality in biology and medicine

The superimposition of a cost function on a universe of discourse serves to systematically select representatives from equivalence classes, with the nature of optimality problems being highly sensitive to the chosen universe and cost function

Topics:

Optimality
Cost
Control
Side Effects
Dated
Article
1986

Organisms as causal systems which are not mechanisms

This essay argues that understanding organisms and complex systems necessitates a fundamental shift in scientific methods and epistemology, moving beyond the simplistic frameworks of traditional physics to accommodate the unique properties of complexity

Topics:

Causality
Complexity
Organisms
Dated
Chapter
1985

Patching and capping of cell membrane receptors as examples of morphogenetic movement

Morphogenesis refers to the processes that generate patterns and forms in biological systems through the spatial interactions of subunits, exemplified by mechanisms like morphogenetic movement, which rearranges these subunits without altering their character or numbers

Topics:

Cells
Morphogenesis
Cell Sorting
Cell Membrane
Dated
Commentary
1979

Pharmaceutical agents act 'synergically'

Topics:

Ergodicity
Structure
Function
Undated
Typed notes
Undated

Phenotype cannot cause genotype

Topics:

Phenotype
Genotype
Causality
Undated
Typed notes
Undated
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